Our technology provides the versatility and controllable high pressures for efficient cell disruption of even the toughest yeast cells like Pichia Pastoris. Other cells including Saccharomyces cerevisiae are disrupted with equal efficiency and for temperature sensitive proteins we have sophisticated cooling systems to protect intracellular contents purity and quality.

However, access to yeast cell contents, including proteins, can be challenging due to the rigid and protective cell structures of some yeasts (and fungi). Our technology can help meet these challenges.

Yeast Cells - Our High Pressure Homogenizers

Controllable process pressure from 1,500 psi (100 bar) to 60,000 psi (4200 bar) - the highest available for HPH.

Sophisticated for temperature control pre-processing, during and after homogenization.

Variable flow rates from 1m to 275ml per minute in the Lab -> 16 l/h to 130 l/h to 1000 l/h at production scale.

Easy to use and sterlize with low ongoing operating costs.

HPH pretreatment can accelerate S. cerevisiae yeast autolysis which may result in higher protein, amino acid and total solids yield.

With yeasts cells that require higher pressures there is often a balance of whether to go to with a high pressure for more disruption in a single pass or to multi pass at lower pressure. Higher pressure results in higher temperature which may, in some cases, be detrimental to protein recovery (which can be counteracted by our cooling systems). We can help advise on HPH processing parameters for your appliation.

Lab Scale Cell Disruptor - modern 'French Press' type.

Laboratory Homogenizer for yeast cell disruption.

Production Scale

Production Homogenizer for Yeasts cell disruption.

Contact us here to discuss your requirements.