Liposomes can be used as a vehicle for administration of pharmaceutical drugs and nutrients as they are able to encapsulate and deliver the active ingredients to targeted areas.
Generally, four basic stages are involved in liposome preparation and there is a choice of different methods within each stage which influence the liposome characteristics.
This summary page focuses on our method of (mechanical) high pressure homogenization (HPH) as provided by our industry-leading homogenising systems.
Liposomes - our High Pressure Homogenizers
Provide rapid reduction of vesicle size and lamellarity to achieve smaller sizes whilst narrowing the distribution.
HPH also presents the opportunity to load the liposomes, locating hydrophilic active substances within the aqueous vesicle core.
Ultra high pressures to 60,000 psi (4200 bar) and processing from 1 ml to 35ml in the Laboratory up to flow rates in excess of 1000 l/hour.
Easy to scale - from Lab to full production systems for continuous processing with repeatable results.
Multiple options for temperature control - both pre-processing and post processing.
Piston Gap and Micro-Channel Device (interaction chamber).
We think we are unique in that we offer interchangeable piston gap (PG) and micro-channel devices (MCD) processing heads for systems. For liposome preparation both types can be effective but we recommend (for production applications) that both technologies are tested.
Vesicle size reduction is a function of pressure, valve type (PG or MCD) and formulation. Typically sizes from micron level to below 50 nanometers / nm can be achieved.
Highly versatile, fully featured bench top instruments with pressures to 60,000 psi (410 MPa, 4200 bar).
For R&D and smaller scale production up to 125 l/hr.
Full scale production systems with flow rates up to 1000 l/hr offering unrivalled performance.