Our high shear, High Pressure Homogenizers excel at liposomes preparation because of their vesicle disruption proficiency that enables rapid reduction of size. This can be achieved at both Lab and Production scale with repeatable results.

Liposomes can be used as a vehicle for administration of pharmaceutical drugs and nutrients as they are able to encapsulate and deliver the active ingredients to targeted areas.

Generally, four basic stages are involved in liposome preparation and there is a choice of different methods within each stage which influence the liposome characteristics.

This summary page focuses on our method of (mechanical) high pressure homogenization (HPH) as provided by our industry-leading homogenising systems.

Liposomes - our High Pressure Homogenizers

Provide rapid reduction of vesicle size and lamellarity to achieve smaller sizes whilst narrowing the distribution.

HPH also presents the opportunity to load the liposomes, locating hydrophilic active substances within the aqueous vesicle core.

Ultra high pressures to 60,000 psi (4200 bar) and processing from 1 ml to 35ml in the Laboratory up to flow rates in excess of 1000 l/hour.

Easy to scale - from Lab to full production systems for continuous processing with repeatable results.

Multiple options for temperature control - both pre-processing and post processing.

Piston Gap and Micro-Channel Device (interaction chamber).

We think we are unique in that we offer interchangeable piston gap (PG) and micro-channel devices (MCD) processing heads for systems. For liposome preparation both types can be effective but we recommend (for production applications) that both technologies are tested.

Vesicle size reduction is a function of pressure, valve type (PG or MCD) and formulation. Typically sizes from micron level to below 50 nanometers / nm can be achieved.

Homogenizing valve - spindle seat arrangement

Homogenizer valve - both Piston Gap and Micro Channel


High Pressure Laboratory Homogenizer for Lipsome formulation

Highly versatile, fully featured bench top instruments with pressures to 60,000 psi (410 MPa, 4200 bar).

Pilot - R&D

High Pressure Pilot Homogenizer for Lipsome preparation

For R&D and smaller scale production up to 125 l/hr.

Production Scale

Lipsome Production Homogenizer system

Full scale production systems with flow rates up to 1000 l/hr offering unrivalled performance.

image of a Lipsome

Please contact us now to discuss your requirements.