Nanoemulsions are kinetically stable liquid-in-liquid dispersions with droplet sizes between 20 and 500 nm that require high energy to be efficiently created.
Our high pressure, high shear technology has advantages over other nanoemulsion formulation methods including sonication techniques.
Nanoemulsions - our High Pressure Homogenizers
Enabling sterile filtration, especially in the pharmaceutical industry - e.g for Vaccine Adjuvants.
With the best particle size control - from nm to μm - producing stable, uniform particle sizes so improving product bioavailability and stability.
Ultra high pressures to 60,000 psi (4200 bar) and processing from Lab R&D scale to volumes up to 2000 l/hour.
Easy to scale systems providing consistent repeatable results.
Multiple options for temperature control incuding pre-heating and rapid post process cooling.
A choice of both Micro channel (interaction chambers) and piston gap processing configurations for optimized processing.
Easy to use, sterlize and maintain. Low ongoing ownership costs.
Flow rates from 1ml to 275ml per minute / 16 L per hour and a wide range of sample sizes from 1m to 32ml.
Pilot - Smaller scale production
Reliable and robust systems up to 125 l/h.
Production Homogenizer systems
Fully featured Production systems with flow rates up to 2000 l/h.
Application notes - Nanoemulsion formulation - our High Pressure Homogenizer
Our versatile SPCH Lab homogenizer - see image above - was used in this test. Some pre-heating - and stirring - of the emulsion formulation was applied immediately before it was pumped in to the Homogenizer. Pre-heating is not often required - but in this test it was part of the specification.
NOTE - we offer multiple options for temperature control - cooling before processing and rapid cooling at the exit point of the Homogenizer - and also pre-heating (often used when processing Liposomes / SLNs).
The objectives of this test was to formulate a nanoemulsion with particle sizes in the range of 50nm to 80mm.
Multiple tests were carried out at different pressures and either 1 pass, or 2 passes, through our STANSTED Homogenizer.
The objective was reached quickly using the following processing parameters:
The sample was processed using our Piston Gap technology at 2500 bar / 36,000 psi / 250 MPa.
One pass and two passes were tested - two passes yielded slightly better results. On other formulations we have found one pass to be sufficient.
The emulsion sample was pre-heated and gently stirred prior to processing.
The processing parameters above reduced average particle sizes to 50nm - so reaching the test objectives. Even lower particle sizes can be achieved in different scenarios.