Our High Pressure Homogenizers can produce the smallest, most uniform particle sizes with tight distributions in Nanoemulsions with great efficiency and with repeatable results.

See application notes bottom of page.

Nanoemulsions are kinetically stable liquid-in-liquid dispersions with droplet sizes between 20 and 500 nm that require high energy to be efficiently created.

Our high pressure, high shear technology has advantages over other nanoemulsion formulation methods including sonication techniques.

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Nanoemulsions - our High Pressure Homogenizers

  Enabling sterile filtration, especially in the pharmaceutical industry - e.g for Vaccine Adjuvants.

  Producing stable, uniform particle sizes with narrow distributions so improving product bioavailability and stability.

  Ultra high pressures to 60,000 psi (4200 bar) and processing from Lab R&D scale to volumes up to 2000 l/hour.

  Easy to scale systems providing consistent repeatable results.

  Multiple options for temperature control incuding pre-heating and rapid post process cooling.

  A choice of both Micro channel (interaction chambers) and piston gap processing configurations for optimized processing.

  Easy to use, sterlize and maintain. Low ongoing ownership costs.

Laboratory Homogenizers

Flow rates from 1ml to 275ml per minute / 16 L per hour and a wide range of sample sizes from 1m to 32ml.

Laboratory Homogenizer for nanoemulsions

Pilot - Smaller scale production

Reliable and robust systems up to 125 l/h.

High Pressure Pilot Homogenizer for Nanoemulsions

Production Homogenizer systems

Fully featured Production systems with flow rates up to 2000 l/h.

Homogenizer system for nano emulsion production

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Application notes - Nanoemulsion formulation - our High Pressure Homogenizer

Our versatile SPCH Lab homogenizer - see photo above - was used in this test. Some pre-heating - and stirring - of the emulsion formulation was applied immediately before it was pumped in to the Homogenizer. Pre-heating is not often required - but in this test it was part of the specification.

NOTE - we offer multiple options for temperature control - cooling before processing and rapid cooling at the exit point of the Homogenizer - and also pre-heating (often used when processing Liposomes / SLNs).

The objectives of this test was to formulate a nanoemulsion with particle sizes in the range of 50nm to 80mm.

Multiple tests were carried out at different pressures and either 1 pass, or 2 passes, through the Homogenizer.

The objective was reached quickly using the following processing parameters:

The sample was processed using our Piston Gap technology at 2500 bar / 36,000 psi / 250 MPa.

One pass and two passes were tested - two passes yielded slightly better results. On other formulations we have found one pass to be sufficient.

The emulsion sample was pre-heated and gently stirred prior to processing.

The processing parameters above reduced average particle sizes to 64.59 nm. Lower particle sizes can be achieved in different scenarios.

The processed samples were characterized for both particle size and PDI using the Zetasizer Nano ZS (Malvern Instruments, UK).

Please contact us now to discuss your requirements.